A crash in Hopkinton, Massachusetts, temporarily closed Interstate 495 near Exit 55 Thursday afternoon.
A medical helicopter was brought in, prompting the highway to be closed, according to the Massachusetts Department of Transportation.
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The cause of the crash wasn't immediately clear, and it wasn't immediately clear how many people were hurt.
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Aerial footage showed wreckage in the woods near the highway.
The highway was fully reopened after about an hour.