A truck carrying sand rolled over on the ramp from Interstate 93 north to I-95 south, closing the ramp for cleanup as well as two lanes of I-95 south, Massachusetts State Police said.
The driver of the tractor-trailer was thrown from the crash and hurt, but expected to survive, police said.
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Footage from the scene showed sand spilled across much of the southbound side of the highway.
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Police didn't immediately share the driver's condition.
This developing news story will be updated when more information is available.